This study provides strong evidence that distinct activation states of beta-arrestin are key for different functional outcomes.
Within this study, molecular simulations reveal at an all-atom level the impact of different activation states of beta-arrestin on the recognition of Fab30. We find that smaller interdomain rotation angles (lower than 11.1 degrees) result in instability of the beta-arrestin-Fab30 complex (measured as RMSD – right panel). Such complex instability is due to clashes between the N-domain (red surface) and the Fab30 (green surface) which are induced by interdomain rotation.
New insights into A highly conserved δ-opioid receptor region determines RGS4 interaction has been obtained in close collaboration with Dr. Zafiroula Georgoussi (accepted in FEBS).
Recent findings on the “Functional Dynamics of Visual Arrestin” are presented in the EMBO Workshop in Nové Hrady. This work is done in close collaboration with Dr. Martha Sommer from the Charité Berlin.
The European Research Network on Signal Transduction (ERNEST) will focus on elucidating how transmembrane signal transduction networks function on the molecular, cellular and physiological level.
Just accepted manuscript in Free Radical Biology and Medicine: “The antioxidant resveratrol acts as a non-selective adenosine receptor agonist” in collaboration with José Luis Albasanz and Mairena Martín from the Universidad de Castilla-La Mancha.
Course of Structural Biology at the Pompeu Fabra University starts on January 7th, 2019. Time: 12:00, Location: AULA 61.303.
Course of Introduction to Drug Research and Development at the Pompeu Fabra University starts on September 25th, 2018 at 17:00, Location: AULA 61.206.
The GPCR simulation project is presented at the Early Career Scientist Forum on GPCR Signal Transduction (ECSF-GPCR) (click).
Course of Structural Biology at the Pompeu Fabra University starts on January 8th, 2018. Time: 12:00, Location: AULA 61.303.
UPF Course “Drug Research and Development” starts on September 26th, 2017. Time: 17:00, Location: AULA 61.127
Check out the first prototype of GPCRmd here!
Course of Structural Biology at the Pompeu Fabra University starts on the 9th of January 2017!